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Interestingly, no tolerance for locomotor effects or anxiolysis appears in ARM-390-treated animals underlying the fact that biased agonist could be used at the behavioral level

Similarly, CAR-M strategies that incorporate anti-inflammatory intracellular domains (e.g., IL-4R) have demonstrated efficacy in reducing inflammation in a renal injury model (117), suggesting a direct application in autoimmune nephritis

Its secretion is linked to the hypothalamic-pituitary-adrenal (HPA) axis, a complex network involving the hypothalamus, pituitary gland, and adrenal glands