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Aside from RUO sales by chemical companies mostly marketing directly to physician practices and/or consumers for human use which is not permitted, others try to operate at risk in this somewhat Grey Market

Chest 121 , 4047 (2002)

The people who write in happy, more often than not, took a moderate, steady dose alongside vitamin C, every morning, for at least a month before judging results

Similarly, a large randomized, double-blind, multicenter trial evaluating high-dose folic acid supplementation (4.0 mg/day) from early pregnancy until delivery in high-risk women found no significant reduction in PE incidence compared with placebo 40