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Probenecid Concomitant administration of oral ketorolac tromethamine and probenecid resulted in decreased clearance and volume of distribution of ketorolac and significant increases in ketorolac plasma levels (total AUC increased approximately threefold from 5.4 to 17.8 mcg/h/mL) and terminal half-life increased approximately twofold from 6.6 to 15.1 hours

This represents a critical advantage over conventional antidepressants that typically require 2-6 weeks to produce therapeutic effects in humans

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GBS may also have a stronger link to the Johnson & Johnson vaccine and has been reported at a rate of one to two cases per million doses