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Several approaches are being investigated to overcome this limitation

doi: 10.1111/j.1750-3639.2006.00021.x 160

J., Criqui, M

And, when the V max values are set to 10% of their normal values, the number of functional hepatocytes decreases to 10% of normal after 40 hours (the red curve), well below the grey bar marking 30% remaining hepatocytes, which is thought to be the threshold for liver failure[10]