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Thus, it is pivotal that novel clinical and preclinical studies on animal models of AD will intervene as preventive treatments with more effective therapies and will focus on early targets that play a clear role in the development of the disease (e.g., cholinergic drugs which can inhibit the enzyme that degrades acetylcholine, and intracellular clearance mechanisms, such as autophagy) (Dubois et al., 2014

Step 2: Spread from both sides of cheeks and gently blend from centre of face outwards

After randomization, participants completed monthly mid-study visits at 1-month (Month 1), 2-month (Month 2), and the end of study visit at 3 months (Month 3) for the final measurement of outcomes of interest, including the final MR scan

These mechanisms lead to the damage or death of neural cells, thereby affecting brain function