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Likewise, PRMT1 and CARM1 were positively correlated with the expression of Palbociclib resistance genes, while they were negatively correlated with the sensitivity genes identified in the PALOMA-2/3 trials comparative biomarker analyses [52, 53] (Supplementary Table 3)

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To determine the types of cell death induced by PA, we treated MCF-7 and SUM-159 cells with Ferrostatin-1 (fer-1, ferroptosis inhibitor) and QVD.OPh (QVD, apoptosis inhibitor), and Necrostatin-1 (necro-1, necrosis inhibitor)