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When human cells are integrated into microfluidic platforms that mimic key physiological parameters, including oxygen gradients, fluid flow, and multicellular tissue interactions, these systems provide improved translational relevance than conventional models [175, 176]

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Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for type 2 diabetes management under the brand name Mounjaro and for chronic weight management as Zepbound

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