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According to a report in Scientific World Journal , Toxic metals such as arsenic, cadmium, lead, and mercury are ubiquitous, have no beneficial role in human homeostasis, and contribute to noncommunicable chronic disease. Researchers have identified that significant exposure to at least 23 different environmental metals (called heavy metals) can contribute to acute or chronic toxicity

Subsequently, ketoglutarate enters the TCA cycle to replenish the mitochondrial citrate pool

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This initiates the controlled release of imaging agents or chemotherapeutic drugs directly at the tumor location [109]