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Glucagon-like peptide 1-mediated delivery of dexamethasone It is widely known that dietary-induced obesity causes chronic peripheral and central inflammation (163)

Branched chained amino-acids (BCAA) are known to stimulate cell growth by the activation of mTORC2, a protein complex that controls protein synthesis in cells by sensing nutrient and energy availability and is also one of the main signaling pathways of IGF-I and insulin (Figure 3)

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These factors support continued research interest despite the disappointing oral efficacy results