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The amount in compounded tirzepatide (typically 0.5-1mg weekly) is well above the RDA but may not fully compensate for absorption issues and increased demands during rapid weight loss

Maximum benefits typically develop over 2-4 weeks as B12 levels normalize throughout your body

NICE Clinical Knowledge Summaries and British Society for Haematology guidelines support B12 supplementation in these clinical contexts, with treatment regimens tailored to the underlying cause

People who were running low on B12 often say they feel less drained within the first several days, which makes it easier to stay active and stick with a routine