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In LS, patients require colonoscopic surveillance at two yearly intervals : Patients with LS are at risk of extracolonic malignancies

Mechanism of Action: 2 adrenoreceptor agonist Peripheral : 2 agonists can directly cause arterial vasoconstriction , which can cause an initial phase of hypertension , before centrally mediated effects predominate, resulting in reduced sympathetic outflow from the CNS, which results in both bradycardia and hypotension (Malayala et al, 2022

k , SMART1-mediated Smurf1 degradation is dependent on CRBN