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Nitric oxide induces CD4+CD25+ Foxp3- regulatory t cells from CD4+CD25- t cells via p53, IL-2, and OX40

Genetic and epigenetic studies Organoids are amenable to genetic editing tools like CRISPR/Cas9, enabling detailed investigations into gene functions, disease mechanisms and epigenetic impacts

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In both the B16F10 melanoma and E.G7-OVA lymphoma model, TDLN-targeting nanoparticle (NP)-conjugate vaccines induced substantially stronger local and systemic cytotoxic CD8+ T-cell responses when compared to non-TDLN-targeting vaccination, leading to enhanced tumor regression and host survival (237)