glutathione prostate cancer synthesis impacts neutrophil-induced cell Patient flow chart. PSA, prostate-specific

Central and peripheral immune responses must both be considered

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Intracellularly, the Fenton reaction is limited, in part, by the lack of free transition metals in cells, but may play a role in oxidative damage after ischemia-reperfusion or under other oxidative stress conditions that involve accumulation of high levels of intracellular hydrogen peroxide and liberation of Fe 2+ from intracellular storage sites (115, 288)