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10.1093/ajcn/nqaa430 Summary Keywords TMAO, L-carnitine, atherosclerosis, endoplasmic reticulum stress, vascular calcification Citation Wang B, Qiu J, Lian J, Yang X and Zhou J (2021) Gut Metabolite Trimethylamine-N-Oxide in Atherosclerosis: From Mechanism to Therapy

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These include: Genetics Brain injuries, such as from falls or accidents Medical conditions, such as diabetes or high blood pressure Poor diet Lack of exercise Smoking Toxins Medications or improper use of medications Social isolation and loneliness Reduction in sleep Some of the reasons these factors can reduce brain health are that they increase inflammation in the brain and can also cause a change in the hormone and nutrient levels in the brain (1)