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However, in this field, various areas remain in which high-quality evidence is lacking, despite their clinical significance

10.3390/ijms20010039 19 ChuB.KonN.ChenD.LiT.LiuT.JiangL.et al (2019)

Oxidative stress and neuroinflammation play a crucial role in the initiation and development of various neurodegenerative diseases [56]

However, in conditions like ischemic stroke and spinal cord injury, CHAC1 promotes neuronal damage by inducing ferroptosis through the depletion of GSH, a critical antioxidant, exacerbating oxidative stress and worsening the injury (Mei et al., 2017