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one or more chemical entities e.g., nicotinamide riboside, nicotinamide mononucleotide the invention encompasses contacting one or more NNMT inhibitors (such as a cation of Formula I or IA, or otherwise disclosed herein) is contacted with a cell expressing NNMT concurrently with one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that modulate intracellular NAD+ levels to provide muscular therapy

doi:10.3389/fneur.2019.00875 Ortega MA, Fraile-Martinez O, Garca-Montero C, et al

Mobile phase A was 50 mM ammonium acetate in water, and mobile phase B was acetonitrile