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Description

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) have been implicated in various aspects of innate immune function, which involves respiratory bursts and inflammasome activation

Fibrosis-related metabolic pathways may also be involved

To quantify the potential impact, we reanalyzed the full enrolled cohort ( n = 216) using two complementary sensitivity approachesa mixed model for repeated measures (MMRM) under a Missing At Random (MAR) assumption and multiple imputation (MI) followed by pooled MMRM