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Therefore, the involvement of microglia in inflammation can have both positive and negative effects on disease progression

Treatment of hSOD1 G93A mouse model of ALS with NR slowed down degeneration of spinal motor neurons and reduced neuroinflammation 68

To give you an example, a woman who, let's say, has four children and then goes on to be a mentor and great matriarchal figure in the lives of her grandchildren and perhaps even her great-grandchildren, would theoretically have as much lifespan extension capability as a woman who has zero children to conserve her biological battery, so to speak, but maybe isn't in a position later on in life to have such a meaningful matriarchal role

Multidisciplinary Management of Advanced Laryngeal Cancer