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233 Colanic acid (capsular isopolysaccharide acid), a common gut bacterial metabolite extracted from five bacterial mutants, has been confirmed to extend the lifespan of nematodes and Drosophila by regulating ER stress and mitochondrial dynamics in host cells

They work by signaling cells to produce proteins like collagen and elastin, which are important for maintaining skin structure and elasticity

Intriguingly, lysosomal and autophagy flux inhibitor Baf-A1 showed similar rescuing effect as DFO

Chandy thinks the phenomenon occurs because the B12 allows the body to put itself right, and if you have had things wrong for a long time, then theres a lot to put right in a small period of time