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Exploiting the tolerant region i of the nonnucleoside reverse transcriptase inhibitor (NNRTI) binding pocket: discovery of potent diarylpyrimidine-typed HIV-1 NNRTIs against Wild-Type and E138K mutant virus with significantly improved water solubility and favorable safety profiles

Abstract Current TB treatment regimens are hindered by drug resistance, numerous adverse effects, and long treatment durations, highlighting the need for me-better treatment regimens

Stupp R, Taillibert S, Kanner A, Read W, Steinberg D, Lhermitte B, et al

Therefore, most cancer cells rely on nutrient transporters that can import extracellular cystine (the oxidized dimer form of cysteine) (, which is a sodium-independent, chloride-dependent, anionic L-cystine/L-glutamate antiporter on the cell surface ( SLC7A11 gene in humans is located on chromosome 4 and the SLC7A11 protein has orthologs in all vertebrates ( and, therefore, serves as the primary transporter for cystine and glutamate ( Extracellular cystine is imported into the cell through SLC7A11 and is converted to cysteine through a NADPH-consuming reduction reaction in the highly reducing atmosphere of the cytosol