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Complementary work has documented activation of the VEGFR2 (Vascular Endothelial Growth Factor Receptor 2) pathway, involved in angiogenesis, along with upregulation of early growth response genes (Egr-1) and the FAK-paxillin transcription factor in studied endothelial cells

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Thus, by regulating M1 macrophage activity, the anti-M1 agent directly reduces inflammation and tissue damage, and indirectly prevents the profibrotic activation of M2 macrophages 27