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The combined four-component algorithm adjusts for age and folate status, in view of the likely increase in serum MAA with age in the elderly, and the increase in serum Hcy in folate deficiency

5-Amino-1MQ alone improved grip strength to a greater degree than rigorous exercise training alone, and combined treatment produced sustained increases in daily running distance that did not taper off in the way exercise-alone groups did, suggesting reduced post-exercise muscle recovery requirement