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They activate multiple pathways promoting cell growth and division by maintaining oxidative stress at a controllable level, drive genetic instability and evolution, promote invasion and metastasis, and shape an immunosuppressive microenvironment (5658)

[159] Vitamin D: Vitamin D, obtained from sunlight exposure and specific foods, interacts with the cornea's vitamin D receptor (VDR), converting to calcitriol and reducing inflammation and oxidative stress, supporting corneal barrier function, influencing systemic calcium absorption, correlating with tear production and dry eye symptoms, and potentially contributing to dry eye disease (DED), with promising results in supplementation for DED improvement

These iodinated tyrosine residues are part of the thyroglobulin molecule, and when the hormone is required, thyroglobulin is broken down, releasing T3 and T4 into the bloodstream (Figure 1)

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