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Therefore, understanding tissue- and metabolism-dependent heterogeneity in mitochondrial signaling is crucial for translating mechanistic insights into clinical applications

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It was found that miR-214 can reduce the level of p53 through the lncRNA PVT1/miR-214/p53 positive feedback loop, thus significantly inhibiting ferroptosis in mice by increasing the amino acid transport of SLC7A11 (Lu and Xu 2020)

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