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Description

APAP-induced senescence is most prevalent among cells at the perinecrotic area, where NAPQI-cys levels are high

Based on the crystal structure, HGF forms dimers, 18 and binds to Met to promote dimerization and in turn autophosphorylation of the receptor at Tyr1234 and Tyr1235 that activates the intrinsic kinase activity, and phosphorylation at Tyr 1349 and Tyr 1356 that activates a docking site for adapter proteins