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337 , 340 ACSL4, as a key driver of ferroptosis, can promote the esterification of polyunsaturated fatty acids, thereby increasing the lipid peroxidation level of cell membranes, while down-regulation of GPX4, the core enzyme of the antioxidant system, will lead to the accumulation of lipid peroxides (such as malondialdehyde [MDA], 4-hydroxy-2-nonenal [4-HNE])

In Collagen , CRC Press: 2018;13956

Furthermore, the GSH levels measured by MRS do not strongly correlate with peripheral GSH levels measured through serum (Mischley et al., 2016)