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Description

Abstract Blood clots are pivotal for haemostasis and regeneration 1 , but they are mechanically weak and form slowly 2 , posing risks for life-threatening haemorrhage and limiting broader applications 3,4,5

535 MTP131 Elamipretide (MTP131) is a tetrapeptide targeted to the inner mitochondrial membrane, reducing ROS production, stabilizing enzyme activity, and improving mitochondrial energy production

Biotechnol., doi: 10.1038/nbt.3294 (2015)

Nonetheless, due to the high evolutionary conservation of the molecular clock, comparative analyses between the naked mole-rat and mice revealed that all major clock genes ( Bmal1, Clock, Per1/2, Cry1/2, Rev-Erb/ , and Ror-s ) are present in the naked mole-rats reference genome ( and are expressed in liver tissue, indicating that its circadian clock remains functional (Ghosh et al., 2021)