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In other types of oncolytic adenoviruses, taking VCN-01 as an example, this oncolytic adenovirus, which combines hyaluronidase expression with RGD and HSG binding domain modifications, has shown significant anti-tumor effects across various types of cancer, such as pancreatic cancer, glioma, osteosarcoma, and melanoma, and has demonstrated good safety and efficacy in clinical studies [273276]

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In order to counteract the excess ROS in the brain, Nrf2 activation triggers the endogenous antioxidative defence system, which in turn causes the overexpression of enzymatic (SOD, CAT, and GPx) and nonenzymatic antioxidants (GSH) (Al-Sabahi et al