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Curr Top Toxicol.1:15360

The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress

Glutathione reductase (GR), an NADPH-dependent enzyme, continuously regenerates reduced glutathione (GSH) from its oxidized form (GSSG), thereby maintaining the intracellular reducing environment required for effective antioxidant defense, proper enzymatic activity, and redox-dependent signaling pathways [36]