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Their prophylactic excision is not justified.8,27 AMS has already been described by several authors and institutions based on clinical characteristics of patients and their personal and/or family history of melanoma, with or without histopathological confirmation of an atypical nevus.3 According to Newton et al.1, AMS can be defined through a scoring system, assigning one point for each feature, as seen in Table 1

The fully functional melanosomes contain all the proteins and enzymes required for biosynthesis of melanin, and the structural matrix proteins form an internal scaffold both to support the architecture of the melanosomes and to serve as a nidus for melanin deposition [22]

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Understanding these differences can help researchers select the most appropriate compound for their investigative goals