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On the other hand, pipermethystine, a water-insoluble substance mainly present in kava leaves has been pointed out as another possible source of human kava hepatotoxicity

Orlando UD, Castillo AF, Medrano MAR, Solano AR, Maloberti PM, Podesta EJ

However, our observation suggests that the option of using normal human sera as a source of immunoaffinity antibodies, following Ig isolation and purification using a recombinant antigen (e.g., GliT), represents a novel approach for readily obtaining monospecific antisera against antigenic A

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