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Beydoun MA, Gamaldo AA, Canas JA, et al

Neurotherapeutics 19 , 17241732 (2022)

In prolonged vasoplegia, the vasoconstrictive effect of intrinsic hormones (adrenaline, noradrenaline, arginine vasopressin, and angiotensin II) is reduced through a combination of hormone depletion, desensitization of adrenergic receptors, and smooth muscle cell hyperpolarisation [12]