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Lipid metabolism and lifespan Lipids are a diverse group of macromolecules, which not only serve as structural components of cellular membranes and as an important energy source, but are also recognized as important bioactive signaling molecules [54]

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Through high-throughput screening approaches, large libraries of compounds can be screened against iPSC-derived cancer cells, leading to the identification of novel drug candidates and personalized treatment options [548, 586]

While we understand that ineffective erythropoiesis, in concert with transfusion therapy, causes systemic iron overload in MDS-RS, the underlying pathophysiology of disturbed heme synthesis and mitochondrial iron accumulation is less well understood