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Disclosures: Melissa Kaltenbach: Nothing to Disclose, David Kaplan: AstraZeneca Inc: Grant/Research Support, Roche Genentech: Independent Contractor, Exact Sciences: Grant/Research Support, Glycotest: Grant/Research Support, Sirtex: Advisor, Exelixis: Advisor, AstraZeneca: Advisor, Marina Serper: Transplant Genomics: Grant/Research Support, Grifols: Grant/Research Support, Eurofins: Grant/Research Support, Therese Bittermann: Nothing to Disclose 2218 DIGITAL PHENOTYPE VARIES BY ALCOHOL USE HISTORY AND HEPATIC ENCEPHALOPATHY Jessica Mellinger 1 Tingting Liu 2 Haila Asefa 3 Patricia Bloom 4 Sal Giorgi 2 Brenda Curtis 5 , 1 University of Michigan Hospitals and Health Centers, 2 Technology and Translational Research Unit, National Institute on Drug Abuse, 3 University of Michigan Hospitals and Health Center, 4 University of Michigan, Michigan Medicine, 5 National Institutes of Health Background: Hepatic encephalopathy (HE) is responsible for substantial cirrhosis-related burden and may be detectable by digital phenotyping

BMS-986497 BMS-986497 (ORM-6151) is a CD33 -targeting antibody-conjugated GSPT1 degrader

Glutathione, celebrated for its remarkable health benefits, is increasingly popular as a supplement