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Thus, an increase in NRF2 activity, reflected by induction of NRF2 target genes, likely represent an important mechanism mediating the protection seen in GCLM KO mice

Cass SH, Williams LA, Rajaram R, Hirata Y, Rice D, Tzeng CD, Katz MHG, Badgwell BD, Wang XS, Ikoma N

Approximately 15%30% of Xi-linked genes avoid this silencing, with patterns differing across cellular context, genetic background and developmental stages [108, 109]