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Vitamin B12 supports liver function and helps in the detoxification process

The clinical translation of those findings to an oral supplement context has not been established through published human pharmacokinetic data

In chemotherapy-sensitive patients, Keap1 (Kelch-like ECH-associated protein 1) binds to NRF2 and mediates NRF2 ubiquitination via the Cul3-E3 ligase complex, promoting its degradation and maintaining NRF2 at low levels [32]