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When applied, Gluconolactone has the same affect on skin as AHAs such as lactic acid

80, 16311635 10.1073/pnas.80.6.1631 [DOI] [PMC free article] [PubMed] [Google Scholar] Khansari N., Springer G

(1998) the gold-standard comparison A 12-week randomized trial enrolled 67 women with moderate-to-severe facial aging and compared four topical formulations: a copper peptide cream, a vitamin C cream, a melatonin cream, and tretinoin

Repeatedly injecting into the same spot may increase the likelihood of skin sensitivity or lumps forming under the skin, which is why site rotation is recommended