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Both population and in vivo evidence indicate that oral Vitamin D supplementation increases cathelicidin levels in specific skin lesions, while topical Vitamin D analogues (e.g., calcipotriol) similarly enhance hCAP18/LL-37 expression in wound models, suggesting that correcting Vitamin D axis hyporesponsiveness may help reverse the age-associated phenotype of AMP deficiency and susceptibility [243, 244]

miRNA profiling of circulating EpCAM(+) extracellular vesicles: promising biomarkers of colorectal cancer

doi: 10.1073/pnas.2201645119 38 ReelJMAbbadiJCoxMA

COVID-19 remains deadly, and has mutated to be more communicable