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Interferon receptor-deficient mice are susceptible to eschar-associated rickettsiosis

PubMed: 38802154 Pincus MR, Bowne WB, Sarafraz-Yazdi E (2023) Clinical Oncology , 7(6): 113, ISSN: 2640-1037 Review introducing and defining Poptosis as a novel mechanism for selective cancer cell killing via peptide-induced transmembrane pore formation, distinct from apoptosis and independent of p53 status

Collectively, these non-clinical data demonstrated a compelling pharmacological profile and an acceptable safety margin, thereby justifying progression to first-in-human studies and informing the initial dose-escalation schemes

& Bohr, V