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half of the lowest-end single daily dose range for dogs and half the single daily dose for cats) and the data listed in Tables I and II, the following breakpoints are recommended for canine and feline isolates

However, the exact mechanisms underlying these phenomena are not yet fully understood

The role of IECs in the coordination of immune pathways is largely dependent on their ability to express surface receptors, namely Toll-like receptors (TLRs), at their apical and basolateral membranes which are used to detect the presence of harmful stimuli (Abreu 2010