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Unfortunately, at present, no more effective measures can completely alleviate or reverse tissue fibrosis, so symptomatic treatments for fibrosis-related symptoms are commonly adopted, like non-steroidal anti-inflammatory drugs (NSAIDs) for muscular pain, injection of botulinum toxin for dystonia, and oxygen therapy or mechanical ventilation for respiratory failure

Alcohol dehydrogenase uses NADH to reduce acetaldehyde to ethanol, regenerating NAD + for glycolysis

It has been reported that BH4 supplementation can restore NO and reduce animal myocardial fibrosis (96)

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