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doi: 10.3748/wjg.v11.i33.5156 232 CassiemWde KockM

[50] Cheng AL, Hsu CH, Lin JK, et al

The An 2019 clinical trial in Annals of Dermatology tested a crosslinked hyaluronic acid microneedle patch loaded with sh-Oligopeptide-1 and Acetyl Hexapeptide-8 against vehicle control in Korean women with peri-orbital wrinkles, and found significant reductions in wrinkle depth and improvements in skin elasticity over 8 weeks [37]