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IOC is a leading cause of mortality in individuals with chronic anemia-related disorders, such as -thalassemia and SCD, who undergo long-term transfusions, affecting approximately 2.5% of chronically transfusion-dependent SCD patients [19, 36, 41]

Glycation of hemoglobin, as observed in diabetes, further compromises its functional capacity and enhances ROS-mediated injury, linking metabolic dysregulation with impaired oxygen transport and accelerated aging processes [35]

Almond milk, coconut water, and warm herbal teasespecially ginger teaare often recommended as gentler options

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