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As a result of oxidation processes intensified by external factors (UV radiation, chemical factors, pathogens), there is an overproduction of reactive oxygen species (ROS) in skin, which is usually accompanied by a reduction in antioxidant capacity, which intensifies, among others, oxidative metabolism of phospholipids to produce lipid peroxidation products, such as small unsaturated aldehydes, including 4-hydroxynonenal (4-HNE) and malondialdehyde (MDA), as well as cyclic fatty acid derivatives [isoprostanes (IsoP), isothromboxanes (IsoTX), isolevuglandins (IsoLG), and isofurans (IsoFS)] [40, 41]

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Allergy 62 (5), 565566