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B12 fortified foods, such as cereals, nondairy milk, and nutritional yeast

In Study JMCH, incidences of Grade 3-4 neutropenia (38% versus 23%), thrombocytopenia (9% versus 5%), febrile neutropenia (9% versus 0.6%), and neutropenic infection (6% versus 0) were higher in patients who received pemetrexed plus cisplatin without vitamin supplementation as compared to patients who were fully supplemented with folic acid and vitamin B12 prior to and throughout pemetrexed plus cisplatin treatment

It reduces the potential gastrointestinal side effects

Patients who dont have a deficiency but are looking to optimize their B12 levels may utilize weekly or monthly injections depending on their response to treatment