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10.1080/00016340701446108 Acta Obstet Gynecol Scand

The leak state is the non-phosphorylating resting state of intrinsic uncoupled or dyscoupled respiration when oxygen flux is maintained mainly to compensate for the proton leak at a high chemiosmotic potential, when ATP synthase is not active

For example, a radiological investigation comparing adolescents with high genetic risk for bipolar disorder and schizophrenia with matched controls, found evidence of significant reduction in coupling in both frontalstriatal and frontalparietal networks, as well as lower recruitment of DLPFC during a sustained attention task (77)

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