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doi: 10.1111/j.1398-9995.2010.02513.x

Quinolinic acid/tryptophan ratios predict neurological disease in SIV-infected macaques and remain elevated in the brain under cART

10.1126/scitranslmed.3009885 46

These findings lend support to the hypothesis that high levels of oxidative stress may contribute to the pathophysiology of depressionthough its effects may be anatomically selective