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Azaman, Z

Here, we provide a systematic discussion of these mechanism by classifying them in alterations (1) that involve steps preceding the binding of cisplatin to DNA (pre-target resistance), (2) that directly relate to DNAcisplatin adducts (on-target resistance), (3) concerning the lethal signaling pathway(s) elicited by cisplatin-mediated DNA damage (post-target resistance) and (4) affecting molecular circuitries that do not present obvious links with cisplatin-elicited signals (off-target resistance)

J Natl Cancer Inst 2001

Key Findings: Cost Not an Indicator of Quality: The cost to obtain a 600-mg dose ranged from just 6 cents to more than 50 cents, with no meaningful difference in quality