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A multicenter, randomized, double blind, placebo-controlled phase II study of PL 14736 enema in the treatment of mild-to-moderate ulcerative colitis

The unique modulatory properties of neurosteroids make these particularly well-suited for targeting comorbid anxiety and depression as well as memory deficits in these patient populations

Healing primarily occurs through primary intention, where the wound edges fuse with minimal granulation tissue formation

Adverse events were mild to moderate in severity, most commonly gastrointestinal disturbance (207 adverse events, 37%), with similar rates across treatment groups