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In the patients daily life, however, it is rare for patients to elevate their legs to that degree

Indeed, GSH, Trx, Grx, Prx (together with the enzymes catalyzing their reduction), and the enzymatic antioxidant defense, as a whole, concur to modulate either ROS concentration, or the availability of cellular thiols, thus regulating the function of a large number of proteins implicated in the induction and/or execution of redox-sensitive pathways

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In vivo, LA exists as free and protein-bound (predominant form) and is formed by the substitution of sulfur groups for hydrogen at positions 6 and 8 of octane groups [26]